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Where do diuretics act? Mechanisms of diuretic drugs Loop diuretics inhibit the sodium-potassium-chloride cotransporter in the thick ascending limb (see above figure). Thiazide diuretics, which are the most commonly used diuretic, inhibit the sodium-chloride transporter in the distal tubule.
Which diuretic is the first line of therapy for hypertension? Thiazide diuretics Thiazides are the most commonly used diuretic agents in the treatment of hypertension. They are recommended as the first line therapy in mild to moderate hypertension in many patients, particularly elderly and black patients.
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